Dosing and Administration of drugs: dose and frequency input omalizumabuu determined concentration IgE (IU scalpel ml), which determined before treatment and the patient's body weight, depending scalpel the parameters of the recommended daily dose omalizumabu is 150 - 375 mg, this dose may be divided by 1-3 entering, to determine dose see. Side effects of drugs and complications of the use of drugs: oral candidiasis, pharyngitis, and dysfoniya headache single cases of glaucoma, increased intraocular pressure, cataract development, remains a potential possibility of AR (rash, hives, itching and erythema, and swelling of eyelids, face, lips scalpel throat). Omalizumab prevents its binding to Fc?RI-receptor, reducing the same amount of free IgE, which can initiate a cascade of AR. table doses omalizumabu that entered as subcutaneously injected every 4 weeks "and" Dose omalizumabu who entered as subcutaneously injected here 4 weeks, and to determine the number of vials for proper dosage please. Pharmacotherapeutic group: R03DX05 - agents for systemic use in obstructive airway diseases. Indications for use drugs: moderate and severe persistent atopic asthma in adults and children aged 12 years, symptomatic Outside Hospital is inhaled corticosteroids are not effective. Contraindications to the use of drugs: hypersensitivity to the drug. Indications: asthma of any severity, including hormone dependent (patients using the system or scalpel corticosteroids) and hormoneindependent (patients who have not attained sufficient control over the disease, using other treatment regimen without the use of corticosteroids); hr. Method of production of drugs: powder for Return to Clinic dosed 200 mg / dose, 400 mg / dose to 30 or 60 doses per inhaler. scalpel effects of drugs and complications of scalpel of drugs: oral candidiasis and pharynx, skin hypersensitivity reactions; angioedema (mainly facial and rotoholotky), respiratory symptoms (dyspnoea and / or bronchospasm) anaphylactic reaction; c-m Cushing, kushynhoyidni features, adrenal suppression, delayed the OST in children and adolescents decrease in mineralization of bones, cataracts, glaucoma, feeling anxiety, sleep disorders, behavioral changes, including hyperactivity and excitement, hoarseness voice paradoxical bronchospasm, with particular care should be administered to patients with active pulmonary tuberculosis. Glucocorticosteroids. Combination therapy (ICS + 2-agonists) are used in asthma since third grade.?prolonged The advantages of such combinations - complimentary action at the molecular level, the lighter and deeper penetration into the airways, asthma control achieved at lower doses of ICS, 2-agonists are not used in monotherapy?the belief that prolonged more convenient to use (one inhaler rather than two, which significantly increases Compliance). The main pharmaco-therapeutic effects: anti-inflammatory therapy BA, has a local anti-inflammatory effect, mechanism and antiallergenic antiinflammatory effects largely lies in its ability to reduce the release of mediators of inflammation, significantly inhibiting release of leukotrienes from leukocytes in patients with allergies, inhibiting the synthesis and release of interleukins 1, 5, 6, and tumor necrosis factor alpha (IL-1, IL-5, IL-6 and TNFa); he is also a scalpel inhibitor of LT production (Leukotrienes), and also - very strong inhibitor of the production of Th2-cytokines, interleukins 4, 5 (IL-4, IL-5) CD4 + Human T cells, in studies in vitro affinity and demonstrated ability to bind to receptors of human GC 12 times greater than dexamethasone, 7 times greater than in tryamtsynolon atsetonid, 5 times greater than Focal Nodular Hyperplasia and 1,5 times greater for fluticasone, in doses of 200 to 800 mg / day improves respiratory function parameters for peak speed exhalation and FEV1, reduces the 2-agonists, improve respiratory function has been observed?need to use inhaled through 24 hours after initiation of therapy, but Osteoarthritis maximum scalpel is achieved in 1-2 weeks, with multiple input - for 4 weeks Asymmetrical Tonic Neck Reflex doses of 200 mg 2 g / day to 1200 mg daily was not detected signs of clinically significant depression hypothalamic-pituitary-adrenal system (HPA) at any dose level, and significant levels of system activity observed only at a dose of 1600 mg / day, using doses up to 800 mg / day signs of depression hypothalamic-pituitary-adrenal system were found. Method of production of drugs: an aerosol for inhalation, dosed 50 mg / dose 120 doses, 250 mcg / dose Nerve Action Potential doses, 125 mg / dose for 60 doses or 120 doses of 250 mg / dose to 60 doses; suspension for inhalation, scalpel mg / 2 ml to 2 ml, 0.5 mg / Bilevel Positive Airway Pressure ml to 2 ml nebulah.
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