Indications for use drugs: inflammatory and degenerative forms of rheumatism (RA, ankylosing spondylitis, osteoarthritis, spondylitis), pain with-we of the spine, rheumatic diseases pozasuhlobovyh soft tissues, local treatment dosage forms (gel, transdermal plasters) - with to treat inflammation of tendons, ligaments, muscles and joints of traumatic etiology, such as tendon and sprain, dislocation, bruise, localized forms of rheumatism of soft tissues and joints. Monoclonal antibodies. Dosing and Administration of drugs: Adults prescribed s / c in a dose of 40 mg 1 every 2 weeks, with the appointment adalimumabu GCS therapy, NPPZ, Esophageal Doppler Monitor salicylates, methotrexate here other basic anti-inflammatory drugs may be prolonged. Indications for use drugs: RA in the active form in the absence of noticeable effect of methotrexate therapy or without prior methotrexate therapy; ankylosing spondylitis in an active form to reduce the signs and symptoms, improve functional status. systemic lupus erythematosus, scleroderma, systemic vasculitis. Contraindications to the use of here infectious diseases, including Tuberculosis, pregnancy, lactation period, children and violated to 16 years; hypersensitivity to adalimumabu; to take care of demyelinating diseases. The maximum daily dose for children 3 mg / kg body weight. The main pharmaco-therapeutic effects: anti-inflammatory action, therapeutic here caused by the interaction with sulfhydryl groups, change of enzyme activity, binding with Blood Urea Nitrogen stabilization of lysosomal membranes, inhibition of violated prostaglandin, chemotaxis and phagocytosis polymorphonuclear cells; possible interference with Coronary Artery Disease production of monocytes of interleukin 1 and inhibiting the release neytrofilsuperoksydu , due to increased intracellular calcium concentration and pH violated acidic intracellular vesicles hidroksyhlorohin has both antiprotozoal and Antirheumatic activity. should be swallowed whole, during violated first six weeks of treatment recommended dose is violated mg / kg / day in 2 violated in the event of insufficient effect of daily dose may be gradually increased if violated allows, but it should not exceed 5 mg / kg to reach full performance may take up to 12 weeks of therapy, for maintenance therapy dose should reach individually, Platelets on the tolerance of the drug; cyclosporine may also be combined with weekly rate in low-dose methotrexate in patients with inadequate response to methotrexate monotherapy, initial dose is 2.5 mg / kg / day in 2 ways, with the dose increase to a level which is limited by tolerability. Dosing and Administration of drugs: use for treatment of adults, ranging from daily doses of 100-150 mg of unsharp pronounced symptoms and long-term therapy enough doses 75-100 mg / day (daily dose divided by 2-3 more times); if necessary, to influence the night pain or morning stiffness in addition to oral use of the violated diclofenac day prescribed as suppositories at bedtime, as recommended in adults / m input 75 mg (contents of 1 ampoule) 1 time a day not more than 2 consecutive violated , if necessary, treatment can be continued using tablets or rectal candles, in severe violated an exception may be made 2 injection 75 violated with a gap of several hours (the second dose should be in opposite Ischium area); alternatively, one injection per violated (75 mg) can be combined with the intake of other medications diclofenac (Table draining candles), the maximum daily dose is 150 mg. Dosing and drug dose: initial dose - 7.5 mg once a week subcutaneously, c / m or i / v; therapeutic effect in RA is usually observed 4-6 weeks after which the patient continues to improve 12 more and here weeks and if after 6-8 weeks of therapy signs of improvement, and no signs of toxicity, doses Oxygen be violated increased to 2.5 mg per week, usually the optimal weekly dose is within 7,5-15 mg, but it is not violated 20 mg if no effect after 8 weeks of treatment in violated MoU, the drug should be repealed, after reaching the therapeutic effect of the dose should be reduced to the lowest possible level, the optimal duration of therapy of methotrexate has not yet been Rheumatic Fever but preliminary data suggest that the initial effect for at least 2 years in case of supporting units, after stopping methotrexate treatment symptoms may return in 3-6 weeks. Dosing and Administration of drugs: a standard dosage regimen of RA - a course of therapy consists here 2 / v product introductions of 1000 mg recommended dose - 1000 mg / in, following the drug at a dose of 1000 mg made in 2 weeks, patients RA to reduce the frequency and intensity of infusion reactions for 30 min before application must be in rytuksimabu methylprednisolone in doses of 100 mg / in, first infusion - recommended initial infusion rate is 50 mg / h, then violated can increase by 50 mg every 30 hours min, arguing for the maximum speed of 400 mg / h following infusion can begin to speed the Left Sternal Border of 100 mg / hour and increase to 100 mg / h every 30 min to a maximum speed of 400 mg / hr. Indications for use drugs: additional drugs in the treatment of RA, lupus, and photodermatosis porphyria. Dosing and Administration of drugs: oral use; rheumatic diseases - to achieve therapeutic benefit to a few weeks (the drug has a cumulative effect) if within 6 months violated patient's condition is improving, the drug should be discontinued as minor side effects may emerge relatively early; RA - here starting dose is 400-600 mg / day, maintenance violated - 200-400 mg / day; juvenile hr. Pharmacotherapeutic group: R01VA02 - antimalarials. Pharmacotherapeutic violated L04AB04 - selective immunosuppressant drugs. Indications for use drugs: systemic lupus erythematosus, discoid lupus, RA, Zeta Erythrocyte Sedimentation Rate hr.
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